Gantry 3 – the new treatment unit for proton therapy at PSI. A staff member of PSI demonstrates the patient positioning. Standing: Prof. Damien Weber, head of the Centre for Proton Therapy at the Paul Scherrer Institute. (Photo: Scanderbeg Sauer Photography)
With millimetre precision, certain tumours can be irradiated at the Paul Scherrer Institute PSI using protons – that is, positively charged elementary particles. PSI is the one place in Switzerland where this especially protective and precise option for radiation therapy is possible. Now PSI, where more than 8,000 patients have already been irradiated successfully, has expanded its capacity through a joint project with the University Hospital Zurich and the University of Zurich, with a state-of-the-art treatment facility: the new, 270-ton machine called Gantry 3.
Villigen, Switzerland, 15-May-2018 — /EuropaWire/ — After four years of planning and construction as well as a one-year test phase, the time has come: The most modern irradiation facility at the Centre for Proton Therapy CPT of the Paul Scherrer Institute PSI – Gantry 3 – is now open. With a total weight of 270 tons and a diameter of 10.5 metres, Gantry 3 is the largest machine installed to date at CPT. The main benefit the collaborators cite with the arrival of Gantry 3 is shorter waiting times for patients with cancer. Damien Weber, head and chairman of the proton therapy centre at PSI: With Gantry 3, we can offer highly effective proton therapy to more patients than ever before, because we have more capacity. That will be especially beneficial for children, for whom a conventional cancer irradiation would be too risky. With the proton therapy, we irradiate the tumour more accurately and better protect the healthy tissue around it.
Radiation oncologist Matthias Guckenberger from the University Hospital Zurich, which collaborates closely with CPT, also has high expectations for the new radiation treatment facility: Half of the patients we refer to the Paul Scherrer Institute are children. Gantry 3 makes it possible to send all eligible patients promptly for proton therapy. In parallel with that, this joint project further strengthens the cooperation between PSI and the University Hospital Zurich. Proton therapy is a highly specialised treatment that belongs at specialised centres and university medical institutions.
Cancer treatment is advanced by many years of experience
The Paul Scherrer Institute has decades-long expertise in the area of proton therapy and has already been able to help more than 8,000 cancer patients. More than 500 of these were children. Years ago, with pioneering contributions such as the development of a new irradiation technique – so-called spot scanning –PSI researchers revolutionised proton therapy. With the introduction of this technique, it has become so precise and low-risk that doctors in ever more countries are using proton therapy to treat cancer patients.
This is because, with spot scanning, even tumours in parts of the body that are close to radiation-sensitive, critical structures can be treated. Among these are, for example, certain brain tumours such as meningiomas, tumours in the ear-nose-and-throat area, tumours near the spinal cord, and several types of connective tissue and bone tumours. With proton therapy and spot scanning, cancer patients who would have been classified as incurable 20 years ago finally have a chance of survival
, Weber says. We are very happy about this, and the many patients who have been healed at PSI alone show that our years of intensive research went in the right direction.
Teamwork for each patient
The good cooperation and the tight exchange between PSI and the University Hospital Zurich, as well as all other Swiss university hospitals and specialised clinics in Aarau, Lucerne, and St. Gallen, have contributed decisively to this success, according to Weber. Each cancer patient receives an individual, personally tailored treatment plan. This can also include other forms of treatment, such as operations or chemotherapy, in addition to proton therapy.
Proton therapy with the spot scanning technique means that a beam of positively charged atomic particles is fired at a tumour, and that the beam scans this tumour from back to front, layer by layer and row by row – until the proton beam has hit every spot on the tumour. Some types of cancer grow around sensitive structures in the body, such as the optic nerve for example, or have a very irregular form. If these tumours are treated with conventional radiation therapy, a much too large area has to be irradiated in order to really hit the whole tumour
, Weber explains. It is precisely with these complicated tumours that the special advantage of proton therapy comes into play: Only with a proton beam can the doctors control how deep in the body the particles should exert their maximum effect. Up to that point they do in fact penetrate other tissues, yet they do very limited damage there. The tissues behind the tumour remain unscathed. Consequently, there are fewer side-effects from proton irradiation than with conventional radiation therapy.
Steel colossus for precision work
To hit the tumour with the proton beam with one-millimetre precision, large and heavy technological equipment is required. The patient doesn’t notice much of this at the treatment facility, seeing only the patient couch in front of a white-clad wall. Its design resembles an oversized wheel and hides the actual gantry. The beam head, from which the proton beam emerges, is in a cabinet above the patient couch. Shielded by thick concrete walls, the beam covers a distance of 50 metres from its source in the particle accelerator to the beam head. Only in the last few metres does it run through the gantry.
A gantry is a rotatable beam guide mounted on a mechanical rotor
, explains physicist Alexander Koschik, project leader for Gantry 3. It consists mainly of a vacuum pipe in which the proton beam is guided on the last couple of metres before the beam head. Gantry 3 can be rotated 180 degrees to the right or to the left. This allows the beam head, and the beam that comes out of it, to be aimed at the tumour from all sides.
Nine primary magnets, which surround the vacuum pipe, steer the protons to the patient as a beam with up to one-millimetre accuracy. Next to the rotor, these magnets are responsible for the weight of Gantry 3. A weight of 220 tons – more than that of a blue whale – must be rotated during irradiation with a concentric precision of 50 micrometres. This is accomplished by two drive motors, just 10 horsepower each.
Close collaboration with Swiss companies
The new machine immediately breaks several records at CPT. Not only is it the largest of the three gantries, but it was also installed in the shortest time to date. To build an irradiation facility like this gantry was a big challenge
, says Damien Weber. It was only possible thanks to the outstanding collaboration with our Swiss industry partners as well as the support of various departments of PSI. Through joint efforts, we have installed cutting-edge technology here for cancer patients.
The first patient at Gantry 3 is expected to be treated in June.
For PSI, Gantry 3 is the first irradiation facility to be constructed jointly with a commercial provider – the company Varian Medical Systems from Cham. Damien Weber comments: In Gantry 3 we brought two different worlds together. The industrial partners with their know-how and PSI with its many years of experience in fundamental research and the development of innovative solutions for proton therapy. That was a learning experience for both.
The greatest challenge: Gantry 3 had to be adapted to CPT’s own particle accelerator as well as the control and safety systems of PSI. The two systems work very differently, especially in terms of the software
, explains Alexander Koschik. It’s as if they speak two different languages and can’t reach an agreement.
To overcome this language barrier
and connect the two systems, PSI researchers and Varian staff developed special interfaces through several years of work. These now function with absolute reliability, and they control, for example, the multi-stage safety systems along the beamline. Knowledge of this technnology also benefits the industrial partners.
The irradiation facility Gantry 3 was financed with money from the lottery of the canton of Zurich as well as PSI’s own funds. The total budget amounted to 25 million Swiss francs.
Text: Sabine Goldhahn
About PSI
The Paul Scherrer Institute PSI develops, builds and operates large, complex research facilities and makes them available to the national and international research community. The institute’s own key research priorities are in the fields of matter and materials, energy and environment and human health. PSI is committed to the training of future generations. Therefore about one quarter of our staff are post-docs, post-graduates or apprentices. Altogether PSI employs 2100 people, thus being the largest research institute in Switzerland. The annual budget amounts to approximately CHF 380 million. PSI is part of the ETH Domain, with the other members being the two Swiss Federal Institutes of Technology, ETH Zurich and EPFL Lausanne, as well as Eawag (Swiss Federal Institute of Aquatic Science and Technology), Empa (Swiss Federal Laboratories for Materials Science and Technology) and WSL (Swiss Federal Institute for Forest, Snow and Landscape Research).
(Last updated in May 2017)
Series of background articles on proton therapy at PSI: https://www.psi.ch/media/proton-therapy
Dr. Ulrike Kliebsch
Science and Information Office
Centre for Proton Therapy CPT
Paul Scherrer Institute, 5232 Villigen PSI, Switzerland
Telephone: +41 56 310 55 82
E-mail: ulrike.kliebsch@psi.ch
Prof. Dr. med. Matthias Guckenberger
Director of the Clinic for Radiation Oncology at University Hospital Zurich
Telephone: +41 44 255 29 30
E-mail: matthias.guckenberger@usz.ch
Dr. Alexander Koschik
Project Leader for Gantry 3
Centre for Proton Therapy CPT
Paul Scherrer Institute, 5232 Villigen PSI, Switzerland
Telephone: +41 56 310 33 17
E-mail: alexander.koschik@psi.ch
SOURCE: Paul Scherrer Institut
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- New research unlocks long tail growth opportunity for the tech industry
- Digi Communications NV announces the availability of the instructions on the 2020 share dividend payment
- Digi Communications NV announces that conditional stock options were granted to several Directors of the Company based on the approval of the general meeting of shareholders from 18 May 2021
- Digi Communications N.V. Announces the Company’s General Shareholders Meeting resolutions adopted on 18 May 2021 approving, amongst others, the 2020 Annual Accounts
- Digi Communications N.V. (“Digi”) announces the Q1 2021 Financial results
- Digi Communications NV announces Investors Call for the Q1 2021 Financial Results
- Digi Communications N.V. announces an Amendment to the 2021 Financial Calendar
- Fastpayhotels Hits an Industry Milestone by Connecting 500 Hotels Per Day Through DerbySoft Technology
- 4 ways to build a more flexible supply chain
- Join the world's leading virtual CBD event for FREE
- DEEPENING STRATEGIC RELATIONSHIP BETWEEN UBC AND PIONEERING DECENTRALISED PLATFORM, MANYONE
- Mono Solutions recognizes Norwegian small business agency with best website 2021 award
- Mono Solutions and Xrysos Odigos unlock new opportunities for small businesses
- Behind the scenes of a 10,000-people online conference: creating a live-event atmosphere and leveraging cybersecurity software
- Largest Supply Chain for Face masks, FFP2, FFP3 and cloth masks
- TRANSMAR AND TRANSMETRICS SIGN DEAL FOR STATE-OF-THE-ART LOGISTICS COLLABORATION
- Amendment of Digi Communications N.V. Financial Calendar for 2021
- 4iG and Digi Communications NV’s Romanian subsidiary have entered into a term sheet with regards to a potential acquisition by 4iG of DIGI Group’s Hungarian operations
- “Building Healthy Relationships and Enhancing Gender Equality”: Young women from Cyprus, Egypt, Lebanon and Jordan come together
- Bring Ventures investit dans Crossborderit (CBIT), DDP et une solution de commerce électronique
- Bring Ventures investiert in Crossborderit (CBIT), eine DDP (geliefert verzollt) und E-Commerce Lösung
- Bring Ventures invests in Crossborderit (CBIT), DDP and ecommerce solution
- Lionspeed GP with Patrick Kolb and Lorenzo Rocco joins forces with CarCollection Motorsport in 2021
- Eurekos, ein klassenbester LMS-Anbieter, hat seine Position im renommierten Fosway 9-Grid™ für Lernsysteme verbessert
- Eurekos, en førsteklasses LMS-udbyder, har forstærket sin position på den prestigefyldte Fosway 9-Grid™ for læringssystemer
- Eurekos, ein erstklassiger LMS-Anbieter, hat seine Position auf dem renommierten Fosway 9-Grid™ für Lernsysteme weiter ausgebaut
- Digi Communications N.V. announces Share transaction made by an executive director of the Company with class B shares
GreenMantra Technologies Announces Exclusive Distribution Relationship with HARKE GROUP
- Digi Communications N.V.: Announces an Amendment to the Financial Calendar for 2021
- Ideanomics Invests $13M in Italian EV Motorcycle Company, Energica
- DigiSky and Asman Technology Announce Global Reseller Agreement
- Neowintech - O Marketplace Da Sua Próxima Solução Financeira
- Neowintech - Il Marketplace per la tua prossima soluzione finanziaria
- PIONEERING DECENTRALISED SECURE MESSAGING PLATFORM MANYONE ANNOUNCES STRATEGIC RELATIONSHIP WITH UNIVERSITY COLLEGE LONDON CENTRE BLOCKCHAIN TECHNOLOGY
- Digi Communications NV announces the release of the 2020 Preliminary Financial Results
- Fraunhofer IGD develops automated robotic arm to scan cultural objects in 3D, now cooperating with Phase One
- Adapt Fast or Disappear – Choosing the Right Supplier
- Digi Communications NV announces Investors Call for the 2020 Preliminary Financial Results
- A URSAPHARM Arzneimittel e a CEBINA anunciam uma parceria com vista a reaproveitar o anti-histamínico azelastina para combater a COVID-19
- URSAPHARM Arzneimittel et CEBINA annoncent un partenariat pour reconvertir l'antihistaminique azélastine afin de lutter contre la COVID-19
- URSAPHARM Arzneimittel y CEBINA anuncian una colaboración para readaptar el antihistamínico azelastine para combatir la COVID-19
- URSAPHARM Arzneimittel and CEBINA announce partnership to repurpose the antihistamine azelastine to combat COVID-19
- ANIL UZUN Will Launch Bass Guitar Lessons Series on Youtube
- Henrik Stampe Appointed CEO for Mono Solutions
- Anna Mossberg leder Nordens största privata AI-lab i Sverige: "Utan AI riskerar svenska företag att förlora sin konkurrensfördel."
- What COVID-19 has taught us about manufacturing & the importance of a digital online marketplace
- Digi Communications N.V. announces: the Supreme Court of Hungary dismissed the Company’s appeal related to the 5G Tender procedure
- Customer Data Platform Industry to Reach $1.5 Billion in 2021: CDP Institute Report
- Editor's pick archive....