(IN BRIEF) The Institute of Cancer Research, London, has welcomed the US FDA approval of capivasertib for patients with PTEN-deficient advanced prostate cancer, marking the first regulatory approval of the targeted drug in prostate cancer. Capivasertib blocks AKT, a cancer-driving … Read the full press release
Posted in Business, Education, European Union, Healthcare, Pharma & Biotech, Science, Security & Safety, Technology, United Kingdom
Tagged 3D protein structure, abiraterone, advanced cancer, advanced prostate cancer, AKT inhibitor, AKT pathway, AKT1 mutations, Astex Pharmaceuticals, AstraZeneca, breast cancer, cancer cell growth, cancer cell survival, cancer progression, Cancer Research Technology Limited, Cancer Research UK, CAPItello-281 trial, CAPItello-291 trial, capivasertib, Capivasertib Gains First Prostate Cancer Approval Following Decades of ICR-Led AKT Research, Centre for Cancer Drug Discovery, drug discovery, European Union, FDA, FDA Approval of Capivasertib Marks New Targeted Treatment Option for Advanced Prostate Cancer, fragment-based drug design, fulvestrant, HER2-negative breast cancer, HR-Positive Breast Cancer, ICR, ICR Welcomes FDA Approval of Capivasertib for PTEN-Deficient Advanced Prostate Cancer, ICR Welcomes Milestone FDA Decision for Targeted Therapy in PTEN-Deficient Prostate Cancer, Nature Communications, Nice, oncology research, overall survival, Phase III Trial, PI3 kinase pathway, PIK3CA mutations, precision oncology, Professor Kristian Helin, Professor Paul Workman, prostate cancer patients, prostate cancer treatment, PTEN-deficient prostate cancer, PTEN-deficient tumours, regulatory approval, small molecule inhibitors, targeted therapy, The Institute of Cancer Research, United Kingdom
(IN BRIEF) Scientists at The Institute of Cancer Research, London, and the University of Oxford have uncovered a mechanism that helps cancer cells survive radiotherapy by repairing radiation-induced DNA damage. The study found that insulin-like growth factor 1 receptor, or … Read the full press release
Posted in Education, Healthcare, Pharma & Biotech, Science, Technology, United Kingdom
Tagged Balmus Laboratory, Blocking Cancer Cell Repair Pathway May Strengthen Future Radiotherapy Strategies, Cancer and Genome Instability Group, cancer cell survival, cancer research, Cancer Research UK, cancer therapy, cell survival mechanisms, chromatin, combination treatments, DNA damage response, DNA repair, DNA-dependent protein kinase catalytic subunit, DNA-PKcs, double-strand breaks, Dr Matthew Ellis, Dr Valentine Macaulay, drug targets, end-joining, genome instability, growth signalling, ICR, IGF-1R, insulin-like growth factor 1 receptor, Medical Research Council, Molecular Oncology, New Study Links Cancer Growth Receptor to DNA Repair After Radiation Treatment, non-homologous end joining, oncology, precision treatment, Professor Wojciech Niedzwiedz, prostate cancer, Prostate Cancer UK, radiation treatment, radiotherapy, Research Reveals How IGF-1R Helps Tumours Survive Radiation-Induced DNA Damage, resistant tumours, Targeting IGF-1R Could Make Cancer Cells More Vulnerable to Radiotherapy, The Institute of Cancer Research, treatment resistance, tumour biology, United Kingdom, University of Cambridge, University of Oxford
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