(IN BRIEF) The Institute of Cancer Research, London, has welcomed the US FDA approval of capivasertib for patients with PTEN-deficient advanced prostate cancer, marking the first regulatory approval of the targeted drug in prostate cancer. Capivasertib blocks AKT, a cancer-driving … Read the full press release
Posted in Business, Education, European Union, Healthcare, Pharma & Biotech, Science, Security & Safety, Technology, United Kingdom
Tagged 3D protein structure, abiraterone, advanced cancer, advanced prostate cancer, AKT inhibitor, AKT pathway, AKT1 mutations, Astex Pharmaceuticals, AstraZeneca, breast cancer, cancer cell growth, cancer cell survival, cancer progression, Cancer Research Technology Limited, Cancer Research UK, CAPItello-281 trial, CAPItello-291 trial, capivasertib, Capivasertib Gains First Prostate Cancer Approval Following Decades of ICR-Led AKT Research, Centre for Cancer Drug Discovery, drug discovery, European Union, FDA, FDA Approval of Capivasertib Marks New Targeted Treatment Option for Advanced Prostate Cancer, fragment-based drug design, fulvestrant, HER2-negative breast cancer, HR-Positive Breast Cancer, ICR, ICR Welcomes FDA Approval of Capivasertib for PTEN-Deficient Advanced Prostate Cancer, ICR Welcomes Milestone FDA Decision for Targeted Therapy in PTEN-Deficient Prostate Cancer, Nature Communications, Nice, oncology research, overall survival, Phase III Trial, PI3 kinase pathway, PIK3CA mutations, precision oncology, Professor Kristian Helin, Professor Paul Workman, prostate cancer patients, prostate cancer treatment, PTEN-deficient prostate cancer, PTEN-deficient tumours, regulatory approval, small molecule inhibitors, targeted therapy, The Institute of Cancer Research, United Kingdom
A new citizen-science project is investigating a possible universal structural pattern in protein 3D architecture The pattern involves amino acids clustering by chemical type into mosaic-like arrangements Findings are based on analysis of over 160,000 protein structures and computational simulations … Read the full press release
Posted in European Union, Healthcare, Pharma & Biotech, Science, Spain, Technology
Tagged 3D protein structure, 3D protein-structure snapshots, 3D structure of proteins, a citizen-science project, amino acid clustering, amino acids, Bioinformatics, biology, biomolecules, biotechnology, citizen science, citizen-science platforms, collaborative science, computational biology, crowdsourced research, data analysis, drug discovery, EU-Citizen Science, European Commission, Francisco Javier Lobo Cabrera, global citizen-science initiative, Horizon 2020, Horizon 2020 programme, image repository, Jmol, Jmol software, José Antonio Prado-Bassas, María Ángeles García-Rosado Delgado, molecular visualization, Mosaic Q pattern, novel 3D protein structural pattern, Pablo de Olavide University, protein 3D structure, protein architecture, protein data analysis, protein research, protein structure, proteins, Proteins Mosaic Q, scientific crowdsourcing, SciStarter, stochastic simulations, structural biology, structural patterns in proteins, University of Seville
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