(IN BRIEF) Roche’s ongoing Phase Ib/IIa Brainshuttle™ AD study of trontinemab shows that 91 percent of participants reach amyloid PET negativity, with ARIA‑E rates under 5 percent. The company has outlined Phase III TRONTIER 1 and 2 trials in early symptomatic Alzheimer’s for 2025, plus a planned … Read the full press release
Posted in Business, Financial, Healthcare, Industrial, Investment, Management, Marketing, News, Pharma & Biotech, Science, Security & Safety, Switzerland, Technology
Tagged Alzheimer’s Association International Conference, amyloid plaques, amyloid‑beta monoclonal antibody, ARIA‑E, blood‑based biomarker, blood‑brain barrier, Brainshuttle, centiloids, clinical dementia rating sum of boxes, cognitive decline, diagnostics, early diagnosis, Elecsys pTau217, Levi Garraway, Matt Sause, PET negativity, Phase Ib/IIa, Phase III TRONTIER 1, Phase III TRONTIER 2, preclinical Alzheimer’s, pTau181, pTau217/Ab42 ratio, Roche, sustainability of clinical trials, TRAVELLER, trontinemab
(IN BRIEF) A team at the Technical University of Munich has developed synthetic macrocyclic peptides that inhibit harmful protein aggregation linked to Parkinson’s disease. The peptides also block the interactions between proteins involved in Alzheimer’s and type 2 diabetes, which … Read the full press release
Posted in Business, Education, Financial, Germany, Healthcare, Industrial, Investment, Management, News, Science, Technology
Tagged Alzheimer’s disease, amyloid plaques, Aphrodite Kapurniotu, biomedicine research, cross-seeding inhibition, DFG, EPFL, German Research Foundation, Helmholtz Center Munich, LMU University Hospital, macrocyclic peptides, metabolic disorders, multifunctional drugs, neurodegenerative diseases, Parkinson's disease, peptide biochemistry, protein aggregation, SFB 1035, synthetic peptides, Technical University of Munich, TUM, type 2 diabetes
(IN BRIEF) Roche presented new data at the AD/PD 2025 International Conference demonstrating that trontinemab, in its Phase Ib/IIa Brainshuttle™ AD study, achieves rapid and dose-dependent reductions of amyloid plaques in the brain, with significant biomarker improvements observed in fluid … Read the full press release
Posted in Austria, Business, Financial, Healthcare, Industrial, Investment, Management, Marketing, Media, News, Pharma & Biotech, Science, Security & Safety, Switzerland, Technology
Tagged AD/PD 2025 International Conference, Alzheimer’s disease, amyloid plaques, ARIA-E, biomarkers, Brainshuttle AD study, cognitive impairment, diagnostic solutions, dose-dependent reduction, Elecsys pTau181 plasma test, Levi Garraway, neurogranin, Phase Ib/IIa study, Phase III programme, pTau181, pTau217, Roche, total tau, trontinemab
(PRESS RELEASE) MUNICH, 09-Jan-2019 — /EuropaWire/ — Defects in the geneTREM2 are linked to increased risk of Alzheimer’s disease. The gene is required to activate immune cells called microglia in the brain, which help to eliminate the neurotoxic deposits that are … Read the full press release
Posted in Education, Germany, Healthcare, Science, Technology
Tagged Alzheimer, Alzheimer's, amyloid plaques, Christian Haass, dementia, disease, geneTREM2, microglia, Neurobiology, RESEARCH
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