- 27 scientific presentations, including long-term data from Calquence in mantle cell lymphoma and updated early-phase trial results in chronic lymphocytic leukaemia
- New data on six medicines and potential new medicines across a variety of blood cancers demonstrate breadth of haematology portfolio
CAMBRIDGE, 29-Nov-2018 — /EuropaWire/ — AstraZeneca, together with Acerta Pharma, its haematology research and development centre of excellence, and MedImmune, its global biologics research and development arm, will present 27 abstracts, including six oral presentations, at the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition in San Diego, USA, December 1-4.
New data include presentations on Calquence (acalabrutinib) and Lumoxiti (moxetumomab pasudotox-tdfk), as well as research findings from AstraZeneca’s early pipeline across a variety of blood cancers.
Dave Fredrickson, Executive Vice President, Head of Oncology Business Unit, said: “In less than a year, we have launched two innovative medicines to treat blood cancers. At this year’s ASH, we will continue our momentum by presenting new results from two important trials of Calquence in mantle cell lymphoma and chronic lymphocytic leukaemia and further showcase our broad pipeline with data from our novel MCL1 and CDK9 inhibitors.”
Updated results for Calquence in chronic lymphocytic leukaemia (CLL)
An oral presentation will focus on new three-year follow-up efficacy and safety results (median 33 months) from the ongoing Phase I/II ACE-CL-001 clinical trial, assessing Calquence monotherapy in a cohort of treatment-naive patients with CLL (Abstract #692).
These data expand on findings previously reported and highlight the promising overall and durable response rates and safety profile in this patient population.
New long-term Calquence data in previously-treated mantle cell lymphoma (MCL)
Long-term follow up data (median 26.3 months) being presented for Calquence further confirm results from the Phase II ACE-LY-004 clinical trial in relapsed or refractory mantle cell lymphoma (Abstract #2876). Initial, pre-planned analysis of this trial served as the basis for the accelerated approval of Calquence for the treatment of adult patients with MCL who have received at least one prior therapy by the US Food and Drug Administration (FDA) in October 2017.
New data from recently-approved Lumoxiti
Results will be presented from trials of Lumoxiti in relapsed or refractory hairy cell leukaemia which evaluated whether minimal residual disease eradication, as measured by different quantitative testing approaches, is associated with improved complete response duration (Abstract #1861).
Early pipeline offers new insights into MCL1 inhibition and resistance
New data from AstraZeneca’s early haematology pipeline will be presented, including four oral presentations on different potential new medicines across multiple blood cancers. The presentations feature new insights into the therapeutic potential of inhibiting the anti-apoptotic protein, myeloid cell leukaemia-1 (MCL1) target.
Key pipeline data that will be presented includes preclinical activity of the novel MCL1 inhibitor AZD5991 in multiple myeloma (Abstract #952), findings on the potential to overcome MCL1 resistance in multiple myeloma (Abstract #472), and data on the influence of myeloma patient-derived MCL1 point mutations in MCL1-inhibitor function (Abstract #951). Data will also be presented on MCL1/CDK9 targeting by AZD5991 and the CDK9 inhibitor AZD4573 (Abstract #768).
Key AstraZeneca, Acerta and MedImmune presentations at ASH 2018:
Lead author | Title | Presentation details |
Calquence (acalabrutinib) | ||
Wang, M | Long-Term Follow-Up of Acalabrutinib Monotherapy in Patients With Relapsed/Refractory Mantle Cell Lymphoma | Poster session
Sunday, December 2, 6:00-8:00 PM Location: San Diego Convention Center, Hall GH |
Byrd, J | Acalabrutinib in Treatment-Naïve (TN) Chronic Lymphocytic Leukemia (CLL): Updated Results from the Phase 1/2 ACE-CL-001 Study | Oral session
Monday, December 3 Presentation time: 10:45 AM Location: San Diego Convention Center, Ballroom 20A |
Kabadi, S | Real World Treatment Patterns, Adverse Events and Healthcare Resource Utilization and Costs Among Chronic Lymphocytic Leukemia (CLL) Patients in the United States | Oral session
Monday, December 3 Presentation time: 3:15 PM Location: San Diego Convention Center, Room 25B |
Lumoxiti (moxetumomab pasudotox) | ||
Arons, E | Molecular Remissions with Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox are Associated with Improved Complete Remission Durations During Phase I and III Testing | Poster session
Saturday, December 1, 6:15-8:15 PM Location: San Diego Convention Center, Hall GH |
Early pipeline | ||
Siu, K | Overcoming MCL1 Resistance in Multiple Myeloma | Oral session
Sunday, December 2 Presentation time: 5:15 PM Location: Marriott Marquis San Diego Marina, Grand Ballroom 7 |
Carter, B | MCL-1/CDK9 Targeting by AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and in Vivo in PDX Model of AML Through Modulation of Cell Death and Novel Metabolic Functions | Oral session
Monday, December 3 Presentation time: 4:00 PM Location: Manchester Grand Hyatt San Diego, Seaport Ballroom F |
Chen, B | Myeloma Patient-Derived MCL1 Point Mutations can Influence MCL1-Inhibitor Function | Oral session
Monday, December 3 Presentation time: 5:00 PM Location: San Diego Convention Center, Ballroom 20D |
Matulis, S | Preclinical Activity of Novel MCL1 Inhibitor AZD5991 in Multiple Myeloma | Oral session
Monday, December 3 Presentation time: 5:15 PM Location: San Diego Convention Center, Ballroom 20D |
NOTES TO EDITORS
About AstraZeneca in haematology
Leveraging its strength in oncology, AstraZeneca has established haematology as one of four key oncology disease areas of focus. The company’s haematology franchise includes two US FDA-approved medicines and a robust global development program for a broad portfolio of potential blood cancer treatments. Acerta Pharma serves as AstraZeneca’s haematology research and development centre of excellence. AstraZeneca partners with like-minded science-led companies to advance the discovery and development of therapies to address unmet need.
In October 2018, AstraZeneca and Innate Pharma announced a global strategic collaboration that included Innate Pharma licensing the US commercial rights of Lumoxiti, and with support from AstraZeneca, will continue EU development and commercialisation, pending regulatory submission and approval.
About AstraZeneca in oncology
AstraZeneca has a deep-rooted heritage in Oncology and offers a quickly-growing portfolio of new medicines that has the potential to transform patients’ lives and the Company’s future. With at least six new medicines to be launched between 2014 and 2020 and a broad pipeline of small molecules and biologics in development, we are committed to advance Oncology as a key growth driver focused on lung, ovarian, breast and blood cancers. In addition to our core capabilities, we actively pursue innovative partnerships and investments that accelerate the delivery of our strategy as illustrated by our investment in Acerta Pharma in haematology.
By harnessing the power of four scientific platforms – Immuno-Oncology, Tumour Drivers and Resistance, DNA Damage Response and Antibody Drug Conjugates – and by championing the development of personalised combinations, AstraZeneca has the vision to redefine cancer treatment and one day eliminate cancer as a cause of death.
About Acerta Pharma
Acerta Pharma, a member of the AstraZeneca Group, is creating novel therapies intended for the treatment of cancer and autoimmune diseases. AstraZeneca acquired a majority stake interest in Acerta Pharma, which serves as AstraZeneca’s haematology research and development centre of excellence. For more information, please visit www.acerta-pharma.com.
About MedImmune
MedImmune is the global biologics research and development arm of AstraZeneca, a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of small molecule and biologic prescription medicines. MedImmune is pioneering innovative research and exploring novel pathways across Oncology, Respiratory, Cardiovascular, Renal and Metabolic Diseases, and Infection and Vaccines. The MedImmune headquarters is located in Gaithersburg, MD, one of AstraZeneca’s three global R&D centres, with additional sites in Cambridge, UK and South San Francisco, CA. For more information, please visit www.medimmune.com.
About AstraZeneca
AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas – Oncology, Cardiovascular, Renal & Metabolism and Respiratory. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.
For more information, please visit astrazeneca.com and follow us on Twitter @AstraZeneca.
CONTACTS
Media Relations | ||
Karen Birmingham | UK/Global | +44 203 749 5634 |
Rob Skelding | UK/Global | +44 203 749 5821 |
Matt Kent | UK/Global | +44 203 749 5906 |
Gonzalo Viña | UK/Global | +44 203 749 5916 |
Jennifer Hursit | UK/Global | +44 203 749 5762 |
Jacob Lund | Sweden | +46 8 553 260 20 |
Michele Meixell | US | +1 302 885 2677 |
Investor Relations | ||
Thomas Kudsk Larsen | +44 203 749 5712 | |
Henry Wheeler | Oncology | +44 203 749 5797 |
Christer Gruvris | Cardiovascular; Metabolism | +44 203 749 5711 |
Nick Stone | Respiratory; Renal | +44 203 749 5716 |
Josie Afolabi | Other | +44 203 749 5631 |
Craig Marks | Finance; Fixed Income | +44 7881 615 764 |
Jennifer Kretzmann | Retail Investors | +44 203 749 5824 |
US toll-free | +1 866 381 7277 |
SOURCE: AstraZeneca
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- Il 18° tour del lago Qinghai si conclude con la celebrazione della "maggiore età"
- La 18ª Vuelta al Lago Qinghai concluye con la celebración de su “mayoría de edad”
- 18e ‘Tour of Qinghai Lake’ wordt afgesloten met een ‘coming-of-age’-viering
- Digi Communications N.V.: Rectification of reports published on 15 Feb, 15 Mar, 15 Apr, 15 May and 14 Jun 2019 regarding legal documents in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 published
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 22 and 26 July 2019
- GEANGO at ENSO ANGO - Summer Culture Retreat in Kyoto 2019
- DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol (15-19 July 2019)
- Nanto Cleantech Inc victorious in BYK-Altana patent opposition lawsuit
- Mono Solutions Joins Bauer Media Group to Strengthen SME Marketing Services Across the Globe
- UK Investors File Lawsuit in the Canaries Against Blue Explorers for Misleading Shareholders
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 8 – 12 July 2019
- Digi Communications N.V. announces Share transaction made by an executive director of the Company with class B shares on 11 July 2019
- OFERTA de casas vacacionales de lujo para menos de €25 por persona por noche este verano
- Noticias de Turismo: este verano sacarás más partido de tu presupuesto vacacional encontrando precios más competitivos
- TRAVEL NEWS: Your holiday spending money stretches even further this summer in Spain
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 1 – 5 July 2019, under the class B shares buy-back program approved by the GSM from 30 April 2019 and the duration of this program
- OncoBeta® chosen as a 2019 Red Herring North America Top 100 Winner
- Global Software Innovator, AnyDesk, Announces Record 100 Million Downloads
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 24 and 28 June 2019
- Digi Communications N.V. announces the launch by RCS & RDS S.A., its subsidiary in Romania, of the Digi Mobil 5G Smart service
- Tauschen Sie Ihren Dripper aus und verändern Sie den Geschmack Ihres Kaffees! HARIO veröffentlicht den Double Mesh Metal Dripper.
- Change your dripper and change the flavor of your coffee! HARIO launches the Double Mesh Metal Dripper
- Matvil Corp. противостоит беспределу судебных властей Молдовы
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 17 – 21 June 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 10 and 14 June 2019
- Digi Communications N.V.: Reporting of legal documents concluded by the company in May 2019 in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 published
- DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions occurred under DIGI symbol between 3 – 7 June 2019
- PDA Explores the Transformation of Healthcare at 4th Annual European Meeting
- ASI President John Cross Named AGMA Chairman
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 27 – 31 May 2019
- Breakthrough on laser powder bed fusion technology brings effective production of larger componentscloser to mainstream
- PDA Announces All-Star Speaker Lineup for Advanced Therapy Medicinal Products Conference
- Digi Communications N.V.: Exercise of stock options by the Executive Directors of the Company
- Digi Communications N.V. announces DIGI Kft., the Hungarian subsidiary of the Company, launches mobile telephony services in Hungary
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 21 and 24 May 2019
- ZYXEL READY WITH 5G SAMPLES IN AUGUST 2019
- Digi Communications N.V. announces the initiation of the share buy-back program as authorized by the Company’s GSM on 30 April 2019
- Digi Communications N.V Q1 2019 Financial Report and the report regarding legal documents for April 2019, in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 released
- Digi Communications N.V. announces the new date of the Conference Call for the presentation of the Q1 2019 Financial Report. Update to the Company’s 2019 Financial Calendar.
- Rhenium-SCT® (SCT= Skin Cancer Therapy) now being offered in Hanau, Germany
- Project consortium aims at driving the adoption of selective laser melting (SLM) for large scale metal parts printing
- Digi Communications N.V. announces the availability of the instructions on the 2018 share dividend payment
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 29 April 2019 – 1 May 2019, under the class B shares buy-back progr
- Biodiversity Report Is Urgent Call to Action Beyond Fixes; Geneva Global Initiative Calls on World Community to Focus on Concrete Actions
- Digi Communications N.V.’s general Shareholders’ meeting resolutions from 30 Apr 2019 approving, amongst others, the 2018 Annual Accounts and the availability of the adopted Annual Financial Report for the year ended Dec 31, 2018
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions occurred under DIGI symbol, 22 – 26 April 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 15 April 2019 – 19 April 2019s
- XPAND Code was successfully scanned from 200 meters/700 feet at Olympics stadium
- Wasser eingießen, Warten und Einschalten
- Digi Communications N.V.: Reporting of legal documents concluded by the company in March 2019 in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 published
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 8 and 12 April 2019
- Snowman releases new EP
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 1 – 5 April 2019
- Streamlining adoption of high-speed and high-resolution surface texturing delivered with the Prometheus project
- Customer Data Platform Institute Launches RealCDP to Reduce CDP Confusion
- ASI Technologies Focuses on the future as ASI Drives, and New AGV Pallet Robot, FRED2500
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 25 March 2019 – 29 March 2019
- Towards a Europe of Stakeholder Nations
- Associazione Veneta Lotta alla Talassemia (AVLT) and the UK Thalassaemia Society (UKTS) Clarification on European Regulatory Status of LENTIGLOBIN™
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 19 March 2019 – 22 March 2019
- A new flagship project on Additive Manufacturing skills aims to maintain Europe leading position in industrial competitiveness
- Jeroen Schouten Named Regional Manager, Europe of AeroGo, Inc.
- Digi Communications N.V. Convocation of the Company’s general shareholders meeting for 30 April 2019 for the approval of, among others, the 2018 Annual Report and of the 2018 Financial Statements
- España arrasa con la competencia y es nombrado como el país ideal para estudiar en el extranjero
- Xverify targets European Email Verification market with local data processing, Dublin office
- Digi Communications N.V. announces the resignation by Mr. Sambor Ryszka from his position as non-executive director of the Company
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 11 and 15 March 2019
- Digi Communications N.V.: Reporting of legal documents concluded by the company in February 2019 in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 published
- Admission of Digi Communications N.V. €200,000,000 5.0% additional senior secured notes due 2023 to the listing on the Official List and trading on Irish Stock Exchange’s Main Securities Market
- Digi Communications N.V. announces the appointment of Dan Ioniță as a non-executive director of RCS & RDS S.A., the Romanian subsidiary of the Company
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 4 and 8 March 2019
- Digi Communications N.V. announces share transaction made by an executive director of the Company with class B shares on 4 march 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 25 February – 1 March 2019
- Digi Communications N.V. announces share transaction made by an executive director of the Company with class B shares on 1 march 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 18 and 22 February 2019
- Digi Communications N.V.: finalization and registration by the Company of the conversion of 1,200,000 A shares into an equal number of class B shares
- Digi Communications N.V.: Exercise of stock options by a PDMR in accordance with the stock option plan for the Group’s Romanian employees
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 11 and 15 February 2019
- Report of legal documents concluded by DIGI Communications N.V. in January 2019 or in other period but effective in January 2019
- Digi Communications N.V. announces Availability of Preliminary Financial Report for the year ended December 31, 2018 for Digi Communications N.V. Group
- Mono Solutions launches a new interface to drive the ultimate do-it-with-me (DIWM) experience
- Digi Communications NV Announces Investor Call on the Preliminary Financial Results for the year ended 31 December 2018
- Digi Communications NV: New date of the Conference Call for the 2018 Preliminary financial results; Update to the 2019 Company’s Financial Calendar
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 4 and 8 February 2019
- R.W. Chelsea Holdings Ltd Starts To Hold Fixed Income Investor Meetings In Vienna, Zurich, Geneva and London
- Digi Communications N.V. successfully increased and priced its Offering at €200,000,000 5.0% additional senior secured notes due 2023
- Digi Communications N.V. to offer additional €125,000,000 5.0% senior secured notes due 2023; new notes will be consolidated and treated as its existing €350,000,000; adjustment on interim unaudited consolidated financial statements for the nine-month period ending September 30, 2018
- World's largest superhero statue to be built in Central Europe
- The resignation of Mr. Bendei Ioan – VP and executive director of RCS&RDS S.A., DIGI COMMUNICATIONS N.V.’s subsidiary in Romania
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 28 January 2019 – 1 February 2019
- RCH Group to Showcase Integrated Selling Solutions at EuroCIS
- Mono and bfound partner to expand digital offerings for small businesses in the Middle East
- Digi Communications N.V. publishes the Independent Limited Assurance Report in accordance with Law 24/2017 (Article 82) and FSA Regulation no. 5/2018
- ERRATA of the reports dated 15 Jan 2019 and 15 Oct 2018 regarding the legal acts concluded by DIGI Communications N.V. in Dec 2018 and Sep 2018
- REVEALED: Experts reveal the best dates to book your summer holiday in Spain
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 21 – 25 January 2019
- Céline Dion visite son premier concept store de vêtements CELINUNUNU à Paris
- Anytime, anywhere tailored learning opportunities for welding professionals and apprentices alike
- i5invest открива офис в България
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 14 - 18 January 2019
- Mono helps Fonecta strengthen their digital presence offering for SMBs
- The Bucharest Tribunal’s decision regarding the investigation conducted by the Romanian National Anti-corruption Directorate with respect to RCS & RDS S.A., Integrasoft S.R.L. and certain of their directors
- Digi Communications N.V.: Exercise of stock options by a PDMR in accordance with the stock option plan approved by the Company for the Romanian employees of the Group in 2017
- Report of legal acts concluded by DIGI Communications N.V. in accordance with Romanian Law no. 24/2017 and FSA Regulation no. 5/2018 for December 2018
- Digi Communications N.V.: resolution of the Board of Directors to convert class 1,200,000 A shares into an equal number of class B shares for the purpose of the ongoing employees and directors stock option plans
- CELINUNUNU OUVRE SON PREMIER POP-UP À PARIS
- DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 07 – 11 January 2019
- Digi Communications NV: Announcement of the Conference Call for the 2018 Preliminary financial results. Update to the 2019 Company’s Financial Calendar
- A new Government Emergency Ordinance imposing additional corporate taxes with impact on the telecommunications sector in Romania
- DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 31 December 2018-04 January 2019
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