(COMMUNIQUÉ DE PRESSE) ENSCHEDE, Netherlands, 28-Feb-2022 — /EuropaWire/ — l’université de Twente, une université technique publique basée à Enschede, aux Pays-Bas, a a annoncé que son professeur associé Kerensa Broersen a obtenu un financement Vici du NWO, le Conseil néerlandais de la recherche.
Kerensa Broersen, professeur associé à le Département de technologie appliquée des cellules souches de la faculté ST de l’UT, étudie comment les bactéries intestinales communiquent avec le cerveau et ce qui se passe dans des maladies telles que la maladie de Parkinson. Cela se fait en utilisant des mini-organes, fabriqués à l’aide de cellules souches, qui imitent les intestins et le cerveau.
COMPRÉHENSION MOLÉCULAIRE DE LA PATHOLOGIE PROCESSUS
Les troubles cérébraux représentent un fardeau mondial débilitant pour la société, nécessitant de toute urgence une compréhension moléculaire approfondie de leurs processus pathologiques pour faire avancer le développement de stratégies de ciblage thérapeutique efficaces.
Bien que l’on connaisse de nombreux aspects localisés au cerveau qui régulent la fonction cérébrale, il est intéressant de noter qu’une caractéristique située à près d’un mètre du cerveau dirige de manière critique l’activité cérébrale et la cognition. Cette caractéristique comprend le microbiote intestinal, ou microbiome, la collection de micro-organismes résidant dans l’intestin, qui est considérée comme interagissant avec le cerveau via l’axe microbiome intestinal-intestin-cerveau.
L’axe microbiome-intestin-cerveau fournit une voie de communication manifeste impliquant l’extension des neurones entraînant l’interaction entre l’intestin et le cerveau. Les perturbations de la richesse et de la diversité du microbiome sont une caractéristique commune à de nombreux troubles liés au cerveau, notamment la neurodégénérescence, les tumeurs cérébrales, la sclérose en plaques, les troubles du spectre autistique et la schizophrénie.
Néanmoins, les molécules, les types cellulaires et les voies de signalisation impliqués dans ce processus multi-tissulaire restent énigmatiques. Les études sur ce sujet restent rares en raison de la complexité multi-organes et des défis pour récapituler avec précision cette complexité au moyen des systèmes modèles actuels de l’axe physiologique humain microbiome-intestin-cerveau.
Ce projet Vici vise à fournir des informations mécanistes fondamentales sur la façon dont l’interaction à longue distance facilite la communication entre le microbiome et le cerveau dans la santé et la maladie en exploitant le potentiel de différenciation des cellules souches pluripotentes induites en organoïdes. ;Kerensa et son équipe vont générer un axe intégré microbiome-intestin-cerveau à partir d’un microbiome polycultivé et d’une connexion intestinale, nerf vague et cerveau dérivée de cellules souches qui récapitule les aspects clés de la physiologie humaine. Le potentiel de ce modèle pour imiter les aspects critiques de l’association cliniquement observée entre la composition du microbiome, l’activité du nerf vague et la fonction cérébrale sera évalué et le modèle sera validé contre les phénomènes de neurodégénérescence associés à la maladie de Parkinson médiés par l’axe microbiome-intestin-cerveau.
À PROPOS DE LA SUBVENTION VICI
Avec les subventions Veni et Vidi, le financement Vici fait partie du programme NWO Talent. Les chercheurs reçoivent un financement pouvant atteindre 1,5 million d’euros. Cela leur permettra de développer une ligne de recherche innovante et de constituer leur propre groupe de recherche pendant cinq ans. Vici est l’une des plus importantes bourses scientifiques personnelles aux Pays-Bas et s’adresse aux chercheurs avancés.
Aujourd’hui, les prix Vici dans deux domaines ont été annoncés ; celles des autres domaines scientifiques suivront plus tard.
AVIS DE NON-RESPONSABILITÉ: La version française de ce communiqué de presse est une traduction du communiqué de presse original, qui est rédigé en anglais, et est uniquement à des fins d’information. En cas de divergence, la version anglaise de ce communiqué de presse prévaudra.
Contact presse:
L.P.W. VAN DER VELDE MSC (LAURENS)
Spokesperson / press officer (available Mon, Wed-Fri)
+31 6 1609 6245
l.vandervelde@utwente.nl
Building: Spiegel kantoortuin
SOURCE: UNIVERSITY OF TWENTE
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