Evotec-Backed Breakpoint Therapeutics Nominates Breakthrough Cancer Treatment Candidate BTX-011 for Clinical Development

Evotec-Backed Breakpoint Therapeutics Nominates Breakthrough Cancer Treatment Candidate BTX-011 for Clinical Development

(IN BRIEF) Breakpoint Therapeutics GmbH, a company focused on developing drugs targeting the DNA Damage Response (DDR), has nominated its first preclinical development candidate, BTX-011, an inhibitor of polymerase theta (Pol θ / POLQ), for the treatment of solid tumors. BTX-011, originating from integrated drug discovery efforts in collaboration with Evotec, exhibits promising potential as a best-in-class therapy. It demonstrates high potency and selectivity, showing efficacy in cancer models when combined with standard PARP inhibitors without adding toxicity to normal cells. With IND-enabling activities underway, BTX-011 could revolutionize cancer therapy by improving efficacy, duration of response, and potentially providing a curative treatment, offering hope for cancer patients worldwide.

(PRESS RELEASE) HAMBURG, 22-Mar-2024 — /EuropaWire/ — Breakpoint Therapeutics GmbH (“Breakpoint”), a company dedicated to the discovery and development of drugs targeting the DNA Damage Response (DDR), announced that it has nominated its first preclinical development candidate, BTX-011, an inhibitor of polymerase theta (Pol θ / POLQ) with best-in-class potential, for the treatment of solid tumours. IND-enabling activities have already commenced.

BTX-011 is an oral, highly potent and selective inhibitor of DNA polymerase theta that shows strong and durable in vivo efficacy in relevant cancer models when combined with standard of care PARP inhibitors. Tumour-specific potentiation of drug efficacy is achieved without adding toxicity or detrimental side effects on normal cells. Combining existing therapies with BTX-011 could deliver superior and synergistic tumour cell killing and inhibit the development of therapy resistance. BTX-011 therefore could transform outcomes for cancer patients, through improving the efficacy and duration of therapy response, and providing a potentially curative treatment.

This potential best-in-class preclinical candidate was discovered leveraging Evotec’s fully integrated small molecule drug discovery and development platform. Breakpoint holds all development and commercial rights to the compound.

Dr Daniel Speidel, Managing Director of Breakpoint Therapeutics, commented: “We are proud to announce this important milestone for the company as we deliver the first preclinical development candidate molecule from Breakpoint’s DDR pipeline. From the beginning, Breakpoint’s commitment has been to select only molecules with best-in-class profile and a clear potential to be transformative for cancer therapy. Our polymerase theta inhibitor has these properties, and we look forward to progressing it into the clinic to deliver benefit to patients.”

Dr Jonathan Hollick, Managing Director and Head of Research, added: “The nomination of BTX-011 as our first DDR candidate drug is the result of a comprehensive drug discovery effort executed in close collaboration with Evotec. By leveraging our expertise in drugging challenging targets and a suite of technologies within Evotec’s integrated drug discovery framework, we have optimised multiple chemical series, each with different modes of action against pol theta, to select compounds that we believe have unparalleled development potential. Based on the strong, durable antitumour efficacy that BTX-011 has displayed in preclinical cancer models, we are excited to take this step towards the clinic where we can tackle the challenge of therapy resistance in oncology.”

Dr Cord Dohrmann, Chief Scientific Officer of Evotec and Advisory Board Member of Breakpoint Therapeutics, commented: “We are very excited to celebrate this milestone, together, with Breakpoint Therapeutics. Since the formation of Breakpoint Therapeutics, there has been strong collaboration to advance early projects through discovery and pre-clinical development. This milestone, marking the progression from target ID to a preclinical development candidate molecule, validates Evotec’s spin-out and virtual operations model. It highlights that the creation aligns well with our strategy of generating upside with an optimal risk-reward profile, advancing highly capital-efficient virtual biotech initiatives with the mission to develop first- and best-in-class drugs, for patients.”

Please follow this link for Breakpoint Therapeutics’ full version of the press release.

Media Contact:

Volker Braun
EVP, Head of Global Investor Relations & ESG
Tel: +49 40 228 999 338
volker.braun@evotec.com

SOURCE: Evotec