ZEISS launches best imaging quality and fast linear scanning with its new compact confocal laser scanning microscope ZEISS LSM 800

Best imaging quality and fast linear scanning

Jena/Germany, 19-1-2015 — /EuropaWire/ — ZEISS is introducing a new compact confocal laser scanning microscope for high-end confocal imaging, ZEISS LSM 800. Tailored to the needs of a broad range of applications in individual research environments, the system complements the recently introduced ZEISS LSM 8 family. With highly sensitive GaAsP detector technology and fast linear scanning, ZEISS LSM 800 provides high image quality and offers enhanced productivity and throughput, as well as greater flexibility in live cell imaging. The optional Airyscan module delivers 1.7 times higher resolution and higher sensitivity than conventional confocal microscopes.

Scientists can resolve even fast movements of labeled proteins thanks to the increased scanning speeds, At an image size of 512 x 512 pixels, they are able to capture events at up to 8 frames per second. ZEISS LSM 800 is continually monitoring and calibrating the scanner position to guarantee a stable field of view and equal pixel integration times over the whole field of view. The patented linear scanning regime gives a constant signal-to-noise level and uniform exposure to the illuminating laser throughout the scanned area, including manipulated regions of interest.

Gallium arsenide phosphide photomultiplier tubes (GaAsP PMTs) display high light collection efficiencies over a broad spectral range. Their low dark noise levels also make them the ideal tool for detecting faint signals in low expressing cells. The gain in signal-to-noise ratio (SNR) will increase productivity by achieving faster scan speeds while preserving high image quality. Low laser powers avoid photobleaching and phototoxicity in live cell imaging applications.

ZEISS LSM 800 is an affordable system with a good price-performance ratio: robust and easy to use, with a small footprint. Minimal setup requirements, minimal maintenance, and self-calibration paired with low overall energy consumption make ZEISS LSM 800 an economical choice.

Dr. Jochen Tham
Carl Zeiss Microscopy GmbH
Phone: +49 3641 64-3949
Fax:
jochen.tham@zeiss.com

ZEISS

ZEISS is an international leader in the fields of optics and optoelectronics. The about 25,000 employees of ZEISS generated revenue of about 4.3 billion euros in fiscal year 2013/14. Founded in 1846 in Jena, the company is headquartered in Oberkochen, Germany. ZEISS has been contributing to technological progress for more than 160 years. ZEISS develops and produces solutions for the semiconductor, automotive and mechanical engineering industries, biomedical research and medical technology, as well as eyeglass lenses, camera and cine lenses, binoculars and planetariums. ZEISS is present in over 40 countries around the globe with more than 40 production facilities, around 50 sales and service locations and over 20 research and development sites. Carl Zeiss AG is fully owned by the Carl Zeiss Stiftung (Carl Zeiss Foundation).

Microscopy

The Microscopy business group is the world’s only one-stop manufacturer of light, X-ray and electron microscopes. Its extensive portfolio enables research and routine applications in the life and materials sciences. The Microscopy business group is headquartered in Jena. Additional production and development sites are located in Oberkochen, Göttingen and Munich, as well as in Cambridge in the UK, in Peabody, MA and Pleasanton, CA in the USA. The business group has around 3,000 employees. It generated revenue of 629 million euros in fiscal year 2012/13.

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ZEISS LSM 800 with Airyscan: Your compact confocal power pack.

Comparison between confocal and Airyscan image. HeLa cells, red: mitochondria membrane, green: microtubuli, magenta: actin fibres; acquired with LSM 800. Scale bar 5 µm. Sample courtesy of A. Seitz, EPFL, Lausanne, Switzerland.