Sanofi Finalizes Blueprint Medicines Deal Adding Ayvakit and Robust SM Pipeline

Sanofi Finalizes Blueprint Medicines Deal Adding Ayvakit and Robust SM Pipeline

(IN BRIEF) Sanofi has completed its purchase of Blueprint Medicines, acquiring the approved systemic mastocytosis therapy Ayvakit/Ayvakyt (avapritinib), along with two pipeline candidates: elenestinib (a KIT D816V inhibitor in Phase 2/3 HARBOR, NCT04910685) and BLU‑808 (a wild‑type KIT inhibitor). The $129.00‑per‑share tender offer, including a contingent right for up to $6.00 more upon milestone achievement, closed on 17 July 2025. Blueprint becomes an indirect, wholly‑owned Sanofi subsidiary and will delist from NASDAQ on 18 July. Funded via cash and commercial paper, the acquisition is immediately margin‑accretive and will boost operating income and EPS after 2026, with no significant impact on Sanofi’s 2025 financial outlook.

(PRESS RELEASE) PARIS, 18-Jul-2025 — /EuropaWire/ — Sanofi has finalized its acquisition of Blueprint Medicines Corporation, integrating a marketed therapy, a robust R&D pipeline, and Blueprint’s specialized expertise in systemic mastocytosis (SM) and other KIT‑driven disorders into its immunology franchise. This transaction strengthens Sanofi’s footprint among allergists, dermatologists, and immunologists, further bolstering its expanding immunology portfolio.

Key assets acquired include Ayvakit (avapritinib), the only approved treatment for both advanced and indolent systemic mastocytosis in the US and EU, and a growing indication in unresectable or metastatic GIST with PDGFRA exon 18 mutations. Blueprint’s late‑stage candidate elenestinib—a potent, selective KIT D816V inhibitor with limited CNS penetration—is now advancing in the Phase 2/3 HARBOR study (NCT04910685) for indolent and smoldering SM. Additionally, Sanofi gains BLU‑808, an investigational oral wild‑type KIT inhibitor targeting mast cell–mediated inflammatory diseases.

The tender offer for all outstanding Blueprint shares, at $129.00 per share plus one contingent right for up to $6.00 per share upon achievement of defined milestones, expired on 17 July 2025 at 17:00 EDST. With all conditions met, Sanofi accepted and is promptly paying for all validly tendered shares. Remaining shares were converted into the same cash and contingent‑right package. Blueprint will cease trading on the NASDAQ Global Select Market as of 18 July 2025.

Sanofi funded the deal with cash on hand and short‑term commercial paper; the acquisition is immediately accretive to gross margin and, post‑2026, to operating income and EPS, without materially altering 2025 guidance.

About Ayvakit
Ayvakit (avapritinib) is the first and only medicine approved by the US Food and Drug Administration (FDA) to treat the root cause of SM. It was FDA approved for the treatment of advanced SM in June 2021 and indolent SM in May 2023. It now is indicated in adults with ISM, adults with advanced SM, including aggressive SM (ASM), SM with an associated hematological neoplasm (SM-AHN) and mast cell leukemia (MCL), and adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) harboring a PDGFRA exon 18 mutation, including PDGFRA D842V mutations. The medicine is approved in the EU as Ayvakyt for the treatment of adults with ISM with moderate to severe symptoms inadequately controlled on symptomatic treatment, adults with ASM, SM-AHN or MCL, after at least one systemic therapy, and adults with unresectable or metastatic GIST harboring the PDGFRA D842V mutation. Globally, the medicine is approved for one or more indications in 16 countries, including China where it is marketed by CStone Pharmaceuticals, paying tiered percentage royalties on sales.

About Sanofi
Sanofi is an R&D driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. We apply our deep understanding of the immune system to invent medicines and vaccines that treat and protect millions of people around the world, with an innovative pipeline that could benefit millions more. Our team is guided by one purpose: we chase the miracles of science to improve people’s lives; this inspires us to drive progress and deliver positive impact for our people and the communities we serve, by addressing the most urgent healthcare, environmental, and societal challenges of our time.
Sanofi is listed on EURONEXT: SAN and NASDAQ: SNY

Sanofi forward-looking statements
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Timothy Gilbert | +1 516 521 2929 | timothy.gilbert@sanofi.com
Léa Ubaldi | +33 6 30 19 66 46 | lea.ubaldi@sanofi.com

Investor Relations
Thomas Kudsk Larsen | +44 7545 513 693 | thomas.larsen@sanofi.com
Alizé Kaisserian | +33 6 47 04 12 11 | alize.kaisserian@sanofi.com
Felix Lauscher | +1 908 612 7239 | felix.lauscher@sanofi.com
Keita Browne | +1 781 249 1766 | keita.browne@sanofi.com
Nathalie Pham | +33 7 85 93 30 17 | nathalie.pham@sanofi.com
Tarik Elgoutni | +1 617 710 3587 | tarik.elgoutni@sanofi.com
Thibaud Châtelet | +33 6 80 80 89 90 | thibaud.chatelet@sanofi.com
Yun Li | +33 6 84 00 90 72 | yun.li3@sanofi.com

SOURCE: Sanofi

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