(IN BRIEF) Researchers at The Institute of Cancer Research, London have created a next-generation PROTAC degrader that successfully eliminates the cancer-related protein Aurora A while overcoming the hook effect that has limited earlier degraders. The new molecule, CCT400028, demonstrates improved … Read the full press release
Posted in Business, Education, Financial, Healthcare, Industrial, Investment, Management, Pharma & Biotech, Science, Technology, United Kingdom
Tagged alisertib, Aurora A kinase, Cancer Research UK, cancer therapeutics, CCT400028, chemical probes, Children’s Brain Tumour Centre of Excellence CBTCE, Gary Newton, glioma, hook effect, Institute of Cancer Research Develops Advanced Aurora A PROTAC Degrader That Overcomes Hook Effect and Improves Stability, Institute of Cancer Research London, Journal of Medicinal Chemistry, leukaemia, Lindsay Evans, Neuroblastoma, New Aurora A Degrader from Institute of Cancer Research Demonstrates Improved Selectivity and Reliability in Cancer Studies, paediatric cancers, Paul Workman, PROTAC, protein degradation technology, targeted protein degradation, University of Kiel
(IN BRIEF) The Institute of Cancer Research and NEOsphere Biotechnologies have announced a new collaboration to accelerate the discovery of molecular glue degrader drugs, an innovative approach in targeted cancer therapy. The partnership will integrate ICR’s proprietary molecular glue library … Read the full press release
Posted in Business, Education, Healthcare, News, Pharma & Biotech, Science, Technology, United Kingdom
Tagged Academic–industry partnership to accelerate rational design of molecular glue degrader drugs for cancer treatment, artificial intelligence, Cancer Drug Discovery, cancer research innovation, Centre for Protein Degradation, computational drug design, E3 ligases, Henrik Daub, high-throughput proteomics, ICR, ICR and NEOsphere Biotechnologies join forces to pioneer systematic discovery of molecular glue degrader therapies, Institute of Cancer Research, Institute of Cancer Research and NEOsphere Biotechnologies partner to advance molecular glue degrader drug discovery, Jonathan Beech, Machine Learning, MGDs, molecular glue degraders, molecular glue library, Monte Rosa Therapeutics, Nature Communications, NEOsphere Biotechnologies, Novartis, proteomics, St Jude Children’s Research Hospital, targeted protein degradation, Zoran Rankovic
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