- In pivotal study, everolimus reduced risk of disease progression by 52%; showed 11.0-month median progression-free survival vs 3.9 months for placebo[1]
- Advanced, progressive, nonfunctional neuroendocrine tumors of GI or lung origin are rare forms of cancer with poor prognoses and limited treatment options[2],[3,[4]
- RADIANT-4 results highlighted at key European cancer congress; worldwide regulatory filings are underway[1]
BASEL, 29-9-2015 — /EuropaWire/ — Novartis announced today results of a Phase III pivotal study showing Afinitor® (everolimus) tablets reduced the risk of progression by 52% (hazard ratio [HR] = 0.48; 95% confidence interval [CI], 0.35-0.67; p<0.00001) vs placebo in patients with advanced, progressive, nonfunctional neuroendocrine tumors (NET) of gastrointestinal (GI) or lung origin. The study, RADIANT-4, will be presented at the European Cancer Congress (ECC) 2015 in Vienna, Austria, and was highlighted in the ECC press conference on Saturday, September 26[1].
Additionally, the data show everolimus, a mammalian target of rapamycin (mTOR) inhibitor, extended median progression free survival (PFS) by 7.1 months: median PFS by central review was 11.0 months (95% CI, 9.23-13.3) in the everolimus arm and 3.9 months (95% CI, 3.58-7.43) in the placebo arm. Overall survival (OS) was a key secondary endpoint of the trial. While the OS data are not mature, the first interim analysis showed a trend favoring the everolimus arm. Additional OS analyses are planned. Another secondary endpoint was best overall response rate; the study found that 64% of patients receiving everolimus experienced at least some degree of tumor shrinkage compared to 26% of those on placebo[1].
Safety was also a secondary endpoint of the trial and adverse events (AEs) were consistent with the known safety profile of everolimus. The most common treatment-related grade 3/4 AEs (>5%) for everolimus and placebo, respectively, were stomatitis (9.0% vs 0.0%), diarrhea (7.0% vs 2.0%) and infections (7.0% vs 0.0%)[1].
“Advanced, progressive, nonfunctional NET of GI or lung origin are rare and aggressive cancers, with limited treatment options,” said James Yao, MD, Professor of Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, and the study’s principal investigator. “These pivotal trial results demonstrate strong evidence for the efficacy of the mTOR inhibitor everolimus in this patient population.”
NET are a rare type of cancer that originate in neuroendocrine cells found throughout the body, and are most often found in the GI tract, lungs or pancreas[5]. NET can be functional or nonfunctional: functional NET produce symptoms caused by the secretion of hormones and other substances; nonfunctional NET may produce symptoms caused by the tumor’s growth, such as intestinal blockage, pain and bleeding[5],[6],[7],[8]. At time of diagnosis, 5%-44% of patients with NET in the GI system and 28% of patients with lung NET have advanced disease, meaning the cancer has spread to other parts of the body and is more difficult to treat[5].
“These results show that everolimus has the potential to be a new, clinically meaningful therapy for patients with advanced, progressive, nonfunctional GI or lung NET, which typically have poor prognoses,” said Alessandro Riva, MD, Global Head, Novartis Oncology Development and Medical Affairs. “Our work with the RADIANT clinical program demonstrates our long-term commitment to NET and has yielded important data that have led to improved outcomes for patients with different types of NET.”
The results of the RADIANT-4 study-part of the largest clinical trial program in patients with advanced NET-will serve as the basis of worldwide regulatory submissions for Afinitor for the treatment of advanced, progressive, nonfunctional GI and lung NET. Afinitor is already approved in more than 95 countries worldwide for locally advanced, metastatic or unresectable progressive NET of pancreatic origin.
About RADIANT-4
RADIANT-4 (RAD001 In Advanced Neuroendocrine Tumors) is a Phase III prospective, double-blind, randomized, parallel group, placebo-controlled, multicenter study. The trial examined the efficacy and safety of everolimus plus best supportive care (BSC) vs placebo plus BSC in 302 patients with progressive, well-differentiated, nonfunctional, advanced NET of GI or lung origin. All patients received BSC during treatment, which excluded antitumor agents such as somatostatin analogues (SSAs). Patients were required to have ceased treatment with SSAs for 4 weeks before study entry. Everolimus demonstrated similar efficacy regardless of whether the patient had prior SSA therapy or not. Patients had no history or active symptoms of carcinoid syndrome, and had documented disease progression within the previous 6 months. Patients were randomized 2:1 to receive either daily everolimus 10 mg or daily placebo orally[1].
The primary endpoint of RADIANT-4 was PFS by central radiology review. Secondary endpoints included safety, OS, best overall response rate (defined as complete response plus partial response) and disease control rate[1].
The safety profile of everolimus was consistent with what has been observed in previous studies of this drug. The most common treatment-related AEs included stomatitis, diarrhea, peripheral edema, fatigue, and rash. At the time of the data analysis cutoff date, the primary reasons for treatment discontinuation were disease progression (37% in the everolimus arm vs 72% in the placebo arm) and adverse events (29% in the everolimus arm vs 7% in the placebo arm). A trend towards improved survival was observed at the time of interim OS analysis [HR=0.64; 95% CI, 0.40-1.05; p=0.037], with a total of 70 deaths recorded at the time of the data cutoff (42 [20.5%] in the everolimus arm and 28 [28.6%] in the placebo arm). The result was not statistically significant, since interim analysis significance threshold was p=0.000213[1].
About Afinitor® (everolimus) tablets
Afinitor® (everolimus) is approved in more than 95 countries, including the United States and throughout the European Union, for locally advanced, metastatic or unresectable progressive neuroendocrine tumors of pancreatic origin. It is also approved in 121 countries including the United States and European Union for advanced renal cell carcinoma following progression on or after vascular endothelial growth factor (VEGF)-targeted therapy.
Afinitor is also approved in more than 100 countries including the United States and European Union for advanced HR+/HER2- breast cancer in combination with exemestane, after prior endocrine therapy.
Everolimus is also available from Novartis for use in certain non-oncology patient populations under the brand names Afinitor® or Votubia®, Certican® and Zortress® and is exclusively licensed to Abbott and sublicensed to Boston Scientific for use in drug-eluting stents.
Indications vary by country and not all indications are available in every country. The safety and efficacy profile of everolimus has not yet been established outside the approved indications. Because of the uncertainty of clinical trials, there is no guarantee that everolimus will become commercially available for additional indications anywhere else in the world.
Important Safety Information about Afinitor® (everolimus) tablets
Afinitor/Votubia can cause serious side effects including lung or breathing problems, infections (including sepsis), and kidney failure, which can lead to death. Patients taking concomitant angiotensin-converting enzyme (ACE) inhibitors may be at an increased risk for angioedema. Mouth ulcers and mouth sores are common side effects. Afinitor/Votubia can affect blood cell counts, kidney and liver function, and blood sugar, cholesterol, and triglyceride levels. Afinitor/Votubia may cause fetal harm in pregnant women. Highly effective contraception is recommended for women of child-bearing potential while receiving Afinitor/Votubia and for up to eight weeks after ending treatment. Women taking Afinitor/Votubia should not breast feed. Fertility in women and men may be affected by treatment with Afinitor/Votubia.
The most common adverse drug reactions (incidence >=10 percent) are mouth ulcers, skin rash, feeling tired or weak, diarrhea, infections (including upper respiratory tract infection, sore throat and runny nose, sinusitis, middle ear infection and pneumonia), absence of menstrual periods, high levels of cholesterol, nausea, decreased appetite, low level of red blood cells, acne, abnormal taste, irregular menstrual periods, inflammation of lung tissue, swelling of extremities or other parts of the body, high level of blood sugar, itching, weight loss, nose bleeds, cough and headache. The most common grade 3-4 adverse drug reactions (incidence >=2 percent) are mouth ulcers, infections (including pneumonia), low level of red blood cells, absence of menstrual periods, high level of blood sugar, feeling tired or weak, diarrhea, low white blood cells, inflammation of lung tissue and spontaneous bleeding or bruising. Cases of hepatitis B reactivation, blood clots in the lung or legs, and pneumocystis jirovecii pneumonia (PJP) have been reported. Abnormalities were observed in hematology and clinical chemistry laboratory tests.
Disclaimer
The foregoing release contains forward-looking statements that can be identified by words such as “underway,” “will,” “planned,” “potential,” “commitment,” “yet,” or similar terms, or by express or implied discussions regarding potential new indications or labeling for everolimus, or regarding potential future revenues from everolimus. You should not place undue reliance on these statements. Such forward-looking statements are based on the current beliefs and expectations of management regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that everolimus will be submitted or approved for any additional indications or labeling in any market, or at any particular time. Nor can there be any guarantee that everolimus will be commercially successful in the future. In particular, management’s expectations regarding everolimus could be affected by, among other things, the uncertainties inherent in research and development, including unexpected clinical trial results and additional analysis of existing clinical data; unexpected regulatory actions or delays or government regulation generally; the company’s ability to obtain or maintain proprietary intellectual property protection; general economic and industry conditions; global trends toward health care cost containment, including ongoing pricing pressures; unexpected safety issues; unexpected manufacturing or quality issues, and other risks and factors referred to in Novartis AG’s current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.
About Novartis
Novartis provides innovative healthcare solutions that address the evolving needs of patients and societies. Headquartered in Basel, Switzerland, Novartis offers a diversified portfolio to best meet these needs: innovative medicines, eye care and cost-saving generic pharmaceuticals. Novartis is the only global company with leading positions in these areas. In 2014, the Group achieved net sales of USD 58.0 billion, while R&D throughout the Group amounted to approximately USD 9.9 billion (USD 9.6 billion excluding impairment and amortization charges). Novartis Group companies employ approximately 120,000 full-time-equivalent associates. Novartis products are available in more than 180 countries around the world. For more information, please visithttp://www.novartis.com.
Novartis is on Twitter. Sign up to follow @Novartis at http://twitter.com/novartis(link is external).
References
[1] Yao J, et al. Everolimus in advanced, nonfunctional neuroendocrine tumors of lung or gastrointestinal origin: Efficacy and safety results from the placebo-controlled, double-blind, multicenter, Phase 3 RADIANT-4 study. European Cancer Congress (ECC) 2015, Vienna, Austria.
[2] American Cancer Society. Gastrointestinal Carcinoid Tumors. Available at http://www.cancer.org/acs/groups/cid/documents/webcontent/003102-pdf.pdf (link is external). Accessed September 2015.
[3] American Cancer Society. Lung Carcinoid Tumors. Available at http://www.cancer.org/acs/groups/cid/documents/webcontent/003117-pdf.pdf (link is external). Accessed September 2015.
[4] Halfdanarson T.R., et al. Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival. Annals of Onc. 2008; 19: 1727-1733.
[5] Yao J, et al. One hundred years after “Carcinoid:” Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008; 26: 3063-72.
[6] Akerstrom G, et al. Timing and extent of surgery in symptomatic and asymptomatic neuroendocrine tumors of the pancreas in MEN 1. Langenbecks Arch Surg. 2002; 386:558-69.
[7] Modlin I, et al. Priorities for improving the management of gasteroenteropancreatic neuroendocrine tumors. J Natl Cancer Inst. 2008;100: 1282-1289.
[8] Modlin I, et al. Current status of gastrointestinal carcinoids. Gastroenterology. 2005;128 :1717-1751.
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- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol 16-20 Dec 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 9-13 Dec 2019
- Reporting of legal documents concluded by DIGI Communications N.V. in November 2019 or in other period but effective in November 2019, in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 2-6 Dec 2019
- Menschenrechtsverletzungen durch Zwangskonvertierungen – Ein internationales Problem
- XPAND has launched “XPAND Code Generator”, a website that automatically issues XPAND Code that can be read from 200 meters/700 feet
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 25-29 Nov 2019
- RCS & RDS S.A., Digi Communications N.V.’s subsidiary in Romania, entered into agreements to operate the telecommunications networks of the Romanian companies Digital Cable Systems S.A., AKTA Telecom S.A. and ATTP Telecommunications S.R.L
- Crafting qualifications to accelerate adoption of Additive Manufacturing
- 100,000 Graduation Ceremony of Shincheonji Theology Center Held over 112 countries
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 18 – 22 Nov 2019
- PDA GMP for APIs Education Webinar Now an "ICH Recognised Training Programme"
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 11 – 15 Nov 2019
- Reporting of legal documents concluded by DIGI Communications N.V. in October 2019 or in other period but effective in October 2019, in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018
- Digi Communications NV announces the release of the Q3 2019 Financial Results
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 4 – 8 Nov 2019
- Digi Communications NV announces Investor Call on the Financial Results for Q3 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 28 Oct – 1 Nov 2019
- Medis to Launch an Innovative 4D Flow Module for Clinical Practice
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 21-25 Oct 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 14-18 Oct 2019
- Reporting of legal documents concluded by DIGI Communications N.V. in September 2019 or in other period but effective in September 2019, in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 7-11 Oct 2019
- RCH to Launch WALLE 8T POS for Real-time Access to Data in the Cloud
- ASI Drives Launches Mark 600, Poised to Replace Internal Combustion Engines
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 30 Sep – 4 Oct 2019
- Il noto Brand di Prodotti Promozionali Personalizzati National Pen lancia il Nuovo Sito Italiano
- Un nouveau look pour Universal Pen relançant son site Web de produits de marque promotionnels
- First non-melanoma skin cancer patients treated with the Rhenium-SCT® in Germany
- Finalyse welcomes Dublin as a new entity to the Group
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 23-27 September 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 16-20 Sep 2019
- VIAJES: LOS 5 DESTINOS MÁS BARATOS PARA ESCAPADAS URBANAS
- TRAVEL NEWS: Malaga tops the list of best value city break destinations in Spain
- Dr. Kurt Lauk, prominent business leader, former chairman of Economic Council in Germany (Wirtschaftsrat), former advisor to Angela Merkel, joins Tachyum
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 9-13 Sep 2019
- DIGI Communications N.V.: Decision regarding the participation to the auction procedure related to wireless broadband services supporting the introduction of 5G in Hungary
- Reporting of legal documents concluded by DIGI Communications N.V. in August 2019 or in other period but effective in August 2019, in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018
- Fight To Fame Expands Its Search for the Next Action Film Star to Europe
- Digi Communications N.V. Announces the availability of Investor’s presentation on the company’s website
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 19 – 23 August 2019
- All occasion personalised pens produced by specialist company Camaloon
- Nicht nur für Messen: Werbemittel Kugelschreiber
- Stylos personnalisés : Camaloon pense à tout
- Camaloon: una Penna da personalizzare per ogni occasione
- Experterna på tryck erbjuder profilerande bläckpennor för varje tillfälle
- Gepersonaliseerde pennen kiezen voor al uw behoeften
- MÁS DE 20 MILLONES DE PRODUCTOS DE PAPELERÍA SON COMPRADOS CADA DÍA
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 12 -16 August 2019
- XPAND K.K. will exhibit at the IFA 2019 as a Japanese cutting-edge IT company
- Reporting of legal documents concluded by DIGI Communications N.V. in July 2019 or in other period but effective in July 2019, in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018
- Digi Communications N.V. Announces the availability of H1 2019 Financial Report (for the six month period ended 30 June 2019)
- PDA Announces Six Regulatory Authorities Speaking at Biomanufacturing in Munich
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 5 and 9 August 2019
- Digi Communications NV Announces Investor Call on the Financial Results for the Half-year ended 30 June 2019
- Customer Data Platform Industry Grew 71% in One Year; Will Reach $1 Billion Revenue in 2019
- Central European Online Travel Agency Group Szallas.hu PLC. further strengthens its international presence
- With The Lure Of High Threadcount Sheets After A Day Trekking, Luxury Travel Blogger THE BOUTIQUE ADVENTURER Champions Chic Solo Explorations
- Digi Communications N.V. announces Syndicated facility agreement concluded between the Digi Group and a syndicate of banks
- LA SCULPTURE DE CEDRIC KOUKJIAN, « LIAISON », SERA EXPOSÉ EN PUBLIC PAR LA COMMISSION CULTURELLE DE COLOGNY, EN SUISSE
- CEDRIC KOUKJIAN’S SCULPTURE, “LIAISON” TO BE EXHIBITED IN PUBLIC BY CULTURAL COMMISSION OF COLOGNY IN SWITZERLAND
- Digi Communications N.V.: Independent Limited Assurance Report issued by the external auditor regarding the information included in the current reports under Law 24/2017 (Article 82) and FSA Regulation no. 5/2018
- Il 18° tour del lago Qinghai si conclude con la celebrazione della "maggiore età"
- La 18ª Vuelta al Lago Qinghai concluye con la celebración de su “mayoría de edad”
- 18e ‘Tour of Qinghai Lake’ wordt afgesloten met een ‘coming-of-age’-viering
- Digi Communications N.V.: Rectification of reports published on 15 Feb, 15 Mar, 15 Apr, 15 May and 14 Jun 2019 regarding legal documents in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 published
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 22 and 26 July 2019
- GEANGO at ENSO ANGO - Summer Culture Retreat in Kyoto 2019
- DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol (15-19 July 2019)
- Nanto Cleantech Inc victorious in BYK-Altana patent opposition lawsuit
- Mono Solutions Joins Bauer Media Group to Strengthen SME Marketing Services Across the Globe
- UK Investors File Lawsuit in the Canaries Against Blue Explorers for Misleading Shareholders
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 8 – 12 July 2019
- Digi Communications N.V. announces Share transaction made by an executive director of the Company with class B shares on 11 July 2019
- OFERTA de casas vacacionales de lujo para menos de €25 por persona por noche este verano
- Noticias de Turismo: este verano sacarás más partido de tu presupuesto vacacional encontrando precios más competitivos
- TRAVEL NEWS: Your holiday spending money stretches even further this summer in Spain
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 1 – 5 July 2019, under the class B shares buy-back program approved by the GSM from 30 April 2019 and the duration of this program
- OncoBeta® chosen as a 2019 Red Herring North America Top 100 Winner
- Global Software Innovator, AnyDesk, Announces Record 100 Million Downloads
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 24 and 28 June 2019
- Digi Communications N.V. announces the launch by RCS & RDS S.A., its subsidiary in Romania, of the Digi Mobil 5G Smart service
- Tauschen Sie Ihren Dripper aus und verändern Sie den Geschmack Ihres Kaffees! HARIO veröffentlicht den Double Mesh Metal Dripper.
- Change your dripper and change the flavor of your coffee! HARIO launches the Double Mesh Metal Dripper
- Matvil Corp. противостоит беспределу судебных властей Молдовы
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 17 – 21 June 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 10 and 14 June 2019
- Digi Communications N.V.: Reporting of legal documents concluded by the company in May 2019 in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 published
- DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions occurred under DIGI symbol between 3 – 7 June 2019
- PDA Explores the Transformation of Healthcare at 4th Annual European Meeting
- ASI President John Cross Named AGMA Chairman
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 27 – 31 May 2019
- Breakthrough on laser powder bed fusion technology brings effective production of larger componentscloser to mainstream
- PDA Announces All-Star Speaker Lineup for Advanced Therapy Medicinal Products Conference
- Digi Communications N.V.: Exercise of stock options by the Executive Directors of the Company
- Digi Communications N.V. announces DIGI Kft., the Hungarian subsidiary of the Company, launches mobile telephony services in Hungary
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 21 and 24 May 2019
- ZYXEL READY WITH 5G SAMPLES IN AUGUST 2019
- Digi Communications N.V. announces the initiation of the share buy-back program as authorized by the Company’s GSM on 30 April 2019
- Digi Communications N.V Q1 2019 Financial Report and the report regarding legal documents for April 2019, in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 released
- Digi Communications N.V. announces the new date of the Conference Call for the presentation of the Q1 2019 Financial Report. Update to the Company’s 2019 Financial Calendar.
- Rhenium-SCT® (SCT= Skin Cancer Therapy) now being offered in Hanau, Germany
- Project consortium aims at driving the adoption of selective laser melting (SLM) for large scale metal parts printing
- Digi Communications N.V. announces the availability of the instructions on the 2018 share dividend payment
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 29 April 2019 – 1 May 2019, under the class B shares buy-back progr
- Biodiversity Report Is Urgent Call to Action Beyond Fixes; Geneva Global Initiative Calls on World Community to Focus on Concrete Actions
- Digi Communications N.V.’s general Shareholders’ meeting resolutions from 30 Apr 2019 approving, amongst others, the 2018 Annual Accounts and the availability of the adopted Annual Financial Report for the year ended Dec 31, 2018
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions occurred under DIGI symbol, 22 – 26 April 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 15 April 2019 – 19 April 2019s
- XPAND Code was successfully scanned from 200 meters/700 feet at Olympics stadium
- Wasser eingießen, Warten und Einschalten
- Digi Communications N.V.: Reporting of legal documents concluded by the company in March 2019 in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 published
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 8 and 12 April 2019
- Snowman releases new EP
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 1 – 5 April 2019
- Streamlining adoption of high-speed and high-resolution surface texturing delivered with the Prometheus project
- Customer Data Platform Institute Launches RealCDP to Reduce CDP Confusion
- ASI Technologies Focuses on the future as ASI Drives, and New AGV Pallet Robot, FRED2500
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 25 March 2019 – 29 March 2019
- Towards a Europe of Stakeholder Nations
- Associazione Veneta Lotta alla Talassemia (AVLT) and the UK Thalassaemia Society (UKTS) Clarification on European Regulatory Status of LENTIGLOBIN™
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 19 March 2019 – 22 March 2019
- A new flagship project on Additive Manufacturing skills aims to maintain Europe leading position in industrial competitiveness
- Jeroen Schouten Named Regional Manager, Europe of AeroGo, Inc.
- Digi Communications N.V. Convocation of the Company’s general shareholders meeting for 30 April 2019 for the approval of, among others, the 2018 Annual Report and of the 2018 Financial Statements
- España arrasa con la competencia y es nombrado como el país ideal para estudiar en el extranjero
- Xverify targets European Email Verification market with local data processing, Dublin office
- Digi Communications N.V. announces the resignation by Mr. Sambor Ryszka from his position as non-executive director of the Company
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 11 and 15 March 2019
- Digi Communications N.V.: Reporting of legal documents concluded by the company in February 2019 in accordance with article 82 of Law no. 24/2017 and FSA Regulation no. 5/2018 published
- Admission of Digi Communications N.V. €200,000,000 5.0% additional senior secured notes due 2023 to the listing on the Official List and trading on Irish Stock Exchange’s Main Securities Market
- Digi Communications N.V. announces the appointment of Dan Ioniță as a non-executive director of RCS & RDS S.A., the Romanian subsidiary of the Company
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 4 and 8 March 2019
- Digi Communications N.V. announces share transaction made by an executive director of the Company with class B shares on 4 march 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 25 February – 1 March 2019
- Digi Communications N.V. announces share transaction made by an executive director of the Company with class B shares on 1 march 2019
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 18 and 22 February 2019
- Digi Communications N.V.: finalization and registration by the Company of the conversion of 1,200,000 A shares into an equal number of class B shares
- Digi Communications N.V.: Exercise of stock options by a PDMR in accordance with the stock option plan for the Group’s Romanian employees
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 11 and 15 February 2019
- Report of legal documents concluded by DIGI Communications N.V. in January 2019 or in other period but effective in January 2019
- Digi Communications N.V. announces Availability of Preliminary Financial Report for the year ended December 31, 2018 for Digi Communications N.V. Group
- Mono Solutions launches a new interface to drive the ultimate do-it-with-me (DIWM) experience
- Digi Communications NV Announces Investor Call on the Preliminary Financial Results for the year ended 31 December 2018
- Digi Communications NV: New date of the Conference Call for the 2018 Preliminary financial results; Update to the 2019 Company’s Financial Calendar
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 4 and 8 February 2019
- R.W. Chelsea Holdings Ltd Starts To Hold Fixed Income Investor Meetings In Vienna, Zurich, Geneva and London
- Digi Communications N.V. successfully increased and priced its Offering at €200,000,000 5.0% additional senior secured notes due 2023
- Digi Communications N.V. to offer additional €125,000,000 5.0% senior secured notes due 2023; new notes will be consolidated and treated as its existing €350,000,000; adjustment on interim unaudited consolidated financial statements for the nine-month period ending September 30, 2018
- World's largest superhero statue to be built in Central Europe
- The resignation of Mr. Bendei Ioan – VP and executive director of RCS&RDS S.A., DIGI COMMUNICATIONS N.V.’s subsidiary in Romania
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 28 January 2019 – 1 February 2019
- RCH Group to Showcase Integrated Selling Solutions at EuroCIS
- Mono and bfound partner to expand digital offerings for small businesses in the Middle East
- Digi Communications N.V. publishes the Independent Limited Assurance Report in accordance with Law 24/2017 (Article 82) and FSA Regulation no. 5/2018
- ERRATA of the reports dated 15 Jan 2019 and 15 Oct 2018 regarding the legal acts concluded by DIGI Communications N.V. in Dec 2018 and Sep 2018
- REVEALED: Experts reveal the best dates to book your summer holiday in Spain
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 21 – 25 January 2019
- Céline Dion visite son premier concept store de vêtements CELINUNUNU à Paris
- Anytime, anywhere tailored learning opportunities for welding professionals and apprentices alike
- i5invest открива офис в България
- Notification shares buy-back: DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol, 14 - 18 January 2019
- Mono helps Fonecta strengthen their digital presence offering for SMBs
- The Bucharest Tribunal’s decision regarding the investigation conducted by the Romanian National Anti-corruption Directorate with respect to RCS & RDS S.A., Integrasoft S.R.L. and certain of their directors
- Digi Communications N.V.: Exercise of stock options by a PDMR in accordance with the stock option plan approved by the Company for the Romanian employees of the Group in 2017
- Report of legal acts concluded by DIGI Communications N.V. in accordance with Romanian Law no. 24/2017 and FSA Regulation no. 5/2018 for December 2018
- Digi Communications N.V.: resolution of the Board of Directors to convert class 1,200,000 A shares into an equal number of class B shares for the purpose of the ongoing employees and directors stock option plans
- CELINUNUNU OUVRE SON PREMIER POP-UP À PARIS
- DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 07 – 11 January 2019
- Digi Communications NV: Announcement of the Conference Call for the 2018 Preliminary financial results. Update to the 2019 Company’s Financial Calendar
- A new Government Emergency Ordinance imposing additional corporate taxes with impact on the telecommunications sector in Romania
- DIGI COMMUNICATIONS N.V. reports to the regulated market the transactions which occurred under the DIGI symbol between 31 December 2018-04 January 2019
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