(IN BRIEF) AstraZeneca’s IMPACT CKD model predicts a significant increase in chronic kidney disease (CKD) across eight countries, with up to 16.5% of the population affected by 2032, including a substantial rise in advanced-stage cases. Presented at the 2024 ISN World Congress of Nephrology, the study underscores the urgent global health crisis of CKD, estimating nearly 125 million people suffering from advanced CKD by 2032. The economic burden, with renal replacement therapy costs reaching approximately $186 billion, and environmental impact, contributing to healthcare’s carbon footprint, highlight the pressing need for early detection and treatment strategies. AstraZeneca’s commitment to mitigating CKD’s impact is evident through initiatives like ACT on CKD, aiming to reduce kidney failure progression rates and elevate CKD awareness on the global policy agenda.
(PRESS RELEASE) CAMBRIDGE, 15-Apr-2024 — /EuropaWire/ — A new modelling analysis by AstraZeneca, IMPACT CKD, forecasts up to 16.5% of the population across eight countries will suffer from chronic kidney disease (CKD) by 2032, including a rise of up to 59.3% in advanced-stage.1 Presented at the 2024 ISN World Congress of Nephrology (WCN’24) in Buenos Aires, the study highlights an urgent and growing global health crisis with profound economic and environmental implications.1 IMPACT CKD is the first study to examine and forecast the vast, multi-dimensional impact of CKD over a 10-year time horizon across eight countries — the United States, Brazil, the United Kingdom, Spain, Germany, the Netherlands, China, and Australia.1
The research estimates nearly 125 million people across these countries will suffer from advanced CKD by 2032, marking a 25% increase since 2022 when the model began.1 The economic toll of renal replacement therapy, including dialysis and transplant, is anticipated to reach approximately $186 billion, and dialysis requirements are expected to surge by over 75%, contributing significantly to healthcare’s carbon footprint — equivalent to adding approximately 17.3 million cars’ worth of CO2 emissions.1
Ruud Dobber, Executive Vice-President, BioPharmaceuticals Business Unit, AstraZeneca, highlights: “Our modelling emphasises the enormous impact CKD could have on patients, economies and the environment. But this future is not inevitable. At AstraZeneca, we are committed to working with global policy makers to reduce the world-wide impact of end-stage CKD and drive earlier diagnosis and treatment to slow or halt progression of disease.”
The IMPACT CKD study is part of AstraZeneca’s Accelerating Change Together (ACT) for CKD initiative, aiming to improve understanding and outcomes of CKD worldwide. Through the ACT on CKD programme, AstraZeneca, alongside the Global Patient Alliance for Kidney Health (GloPAKH), has launched ‘Make the Change for Kidney Health’ campaign. This initiative seeks to elevate CKD on the global policy agenda, advocating for comprehensive and effective disease management strategies to combat this escalating health challenge.
Notes
CKD
CKD is a serious, progressive condition defined by decreased kidney function (shown by reduced eGFR or markers of kidney damage, or both, for at least three months).2 Nearly 850 million people worldwide are affected by CKD,3 with the majority undiagnosed.2 The most common causes of CKD are diabetes, hypertension and glomerulonephritis.4 CKD is associated with significant patient morbidity and an increased risk of cardiovascular (CV) events, such as heart failure (HF), which drives premature death.5 In its most severe form, known as kidney failure, kidney damage and deterioration of kidney function have progressed to the point where dialysis or kidney transplantation are required.6 The majority of patients with CKD will die from CV causes before reaching kidney failure.7
IMPACT CKD
IMPACT CKD is an innovative study that incorporates a sophisticated simulation model to unveil a holistic projection of the extensive impacts of chronic kidney disease (CKD) across clinical, economic, societal, and environmental dimensions.1 This landmark analysis delivers the first-ever, 10-year outlook on the impact of CKD, providing insight for the United States, Brazil, the United Kingdom, Spain, Germany, the Netherlands, China, and Australia.1 Emphasizing the critical importance of early CKD detection and treatment, the study offers strategic insights aimed at substantially mitigating the disease’s multi-dimensional burden.1
ACT on CKD
ACT on CKD is a programme by AstraZeneca to transform kidney health through partnerships aimed at reducing the proportion of patients progressing to kidney failure by 20% by 2025. To realise this ambition, the programme supports initiatives that aim to raise awareness of the burden of CKD and its consequences, expand early detection and drive optimisation of treatment to improve patient outcomes. To further support people at risk of CKD, we also look to achieve sustainable change through health policy reforms.
We want to provide patients, healthcare providers (HCPs) and decision makers with the necessary information to drive change. As a part of our broader contribution to building knowledge around CKD we continue to generate evidence to help advance clinical practice: DISCOVER-CKD shows a lack of urine albumin-creatinine ratio (UACR) testing and adherence to Kidney Disease Improving Global Outcomes (KDIGO) guidelines; REVEAL-CKD shows the extent of the gaps in early detection of CKD and the clear benefits of diagnosing early; INSIDE-CKD shows the unsustainable future burden of CKD and potential benefits to the healthcare system of improved management; PACE-CKD shows CKD is associated with a poorer quality of life not only for patients but also their carers; and IMPACT CKD provides modelling of the future CKD burden for public health policy planning, including societal and environmental impact.
The World Congress of Nephrology (WCN)
The World Congress of Nephrology (WCN) is the annual scientific, educational, and networking meeting of the International Society of Nephrology (ISN).8 The ISN is a global professional association dedicated to advancing kidney health worldwide since 1960 through education, grants, research, and advocacy.8
AstraZeneca in CVRM
Cardiovascular, Renal and Metabolism (CVRM), part of BioPharmaceuticals, forms one of AstraZeneca’s main disease areas and is a key growth driver for the Company. By following the science to understand more clearly the underlying links between the heart, kidneys, liver and pancreas, AstraZeneca is investing in a portfolio of medicines for organ protection by slowing or stopping disease progression, and ultimately paving the way towards regenerative therapies. The Company’s ambition is to improve and save the lives of millions of people, by better understanding the interconnections between CVRM diseases and targeting the mechanisms that drive them, so we can detect, diagnose and treat people earlier and more effectively.
AstraZeneca
AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on social media @AstraZeneca
References
1. Rao N, et al. Multidimensional Burden of Chronic Kidney Disease in Eight Countries: Insights from the IMPACT CKD Study. Presented at: WCN 2024, 13-16 April 2024, Buenos Aires, Argentina.
2. Bikbov B, et al. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395(10225):709-733.
3. Jager KJ, et al. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Nephrol Dial Transplant. 2019;34(11):1803-1805.
4. National Kidney Foundation [Internet]. Chronic Kidney Disease (CKD); [cited 2024 March 25]. Available from: https://www.kidney.org/atoz/content/about-chronic-kidney-disease.
5. Centers for Disease Control and Prevention (CDC) [Internet]. Chronic Kidney Disease: Common – Serious – Costly; [cited 2024 March 25]. Available from: https://www.cdc.gov/kidneydisease/prevention-risk/CKD-common-serious-costly.html.
6. Centers for Disease Control and Prevention (CDC) [Internet]. Chronic kidney disease in the United States; 2021 [cited 2024 March 25]. Available from: https://www.cdc.gov/kidneydisease/pdf/Chronic-Kidney-Disease-in-the-US-2021-h.pdf.
7. Briasoulis A, et al. Chronic kidney disease as a coronary artery disease risk equivalent. Curr Cardiol Rep. 2013;15(3):340.
8. WCS [Internet]. ISN World Congress of Nephrology (WCN’24) Abstract Embargo Policy [cited 2024 March 25]. Available from: https://www.theisn.org/wcn/wp-content/uploads/sites/6/2023/06/WCN24-Abstract-Embargo-Policy.pdf.
Veeva ID: Z4-63620
Date of Preparation: April 2024
Media Contact:
Tel: +44 (0)1223 344 800
email: global-mediateam@astrazeneca.com
SOURCE: AstraZeneca
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- Digi Communications N.V. (“Digi”) announces the Q1 2021 Financial results
- Digi Communications NV announces Investors Call for the Q1 2021 Financial Results
- Digi Communications N.V. announces an Amendment to the 2021 Financial Calendar
- Fastpayhotels Hits an Industry Milestone by Connecting 500 Hotels Per Day Through DerbySoft Technology
- 4 ways to build a more flexible supply chain
- Join the world's leading virtual CBD event for FREE
- DEEPENING STRATEGIC RELATIONSHIP BETWEEN UBC AND PIONEERING DECENTRALISED PLATFORM, MANYONE
- Mono Solutions recognizes Norwegian small business agency with best website 2021 award
- Mono Solutions and Xrysos Odigos unlock new opportunities for small businesses
- Behind the scenes of a 10,000-people online conference: creating a live-event atmosphere and leveraging cybersecurity software
- Largest Supply Chain for Face masks, FFP2, FFP3 and cloth masks
- TRANSMAR AND TRANSMETRICS SIGN DEAL FOR STATE-OF-THE-ART LOGISTICS COLLABORATION
- Amendment of Digi Communications N.V. Financial Calendar for 2021
- 4iG and Digi Communications NV’s Romanian subsidiary have entered into a term sheet with regards to a potential acquisition by 4iG of DIGI Group’s Hungarian operations
- “Building Healthy Relationships and Enhancing Gender Equality”: Young women from Cyprus, Egypt, Lebanon and Jordan come together
- Bring Ventures investit dans Crossborderit (CBIT), DDP et une solution de commerce électronique
- Bring Ventures investiert in Crossborderit (CBIT), eine DDP (geliefert verzollt) und E-Commerce Lösung
- Bring Ventures invests in Crossborderit (CBIT), DDP and ecommerce solution
- Lionspeed GP with Patrick Kolb and Lorenzo Rocco joins forces with CarCollection Motorsport in 2021
- Eurekos, ein klassenbester LMS-Anbieter, hat seine Position im renommierten Fosway 9-Grid™ für Lernsysteme verbessert
- Eurekos, en førsteklasses LMS-udbyder, har forstærket sin position på den prestigefyldte Fosway 9-Grid™ for læringssystemer
- Eurekos, ein erstklassiger LMS-Anbieter, hat seine Position auf dem renommierten Fosway 9-Grid™ für Lernsysteme weiter ausgebaut
- Digi Communications N.V. announces Share transaction made by an executive director of the Company with class B shares
- Digi Communications N.V.: Announces an Amendment to the Financial Calendar for 2021
- Ideanomics Invests $13M in Italian EV Motorcycle Company, Energica
- DigiSky and Asman Technology Announce Global Reseller Agreement
- Neowintech - O Marketplace Da Sua Próxima Solução Financeira
- Neowintech - Il Marketplace per la tua prossima soluzione finanziaria
- PIONEERING DECENTRALISED SECURE MESSAGING PLATFORM MANYONE ANNOUNCES STRATEGIC RELATIONSHIP WITH UNIVERSITY COLLEGE LONDON CENTRE BLOCKCHAIN TECHNOLOGY
- Digi Communications NV announces the release of the 2020 Preliminary Financial Results
- Fraunhofer IGD develops automated robotic arm to scan cultural objects in 3D, now cooperating with Phase One
- Adapt Fast or Disappear – Choosing the Right Supplier
- Digi Communications NV announces Investors Call for the 2020 Preliminary Financial Results
- A URSAPHARM Arzneimittel e a CEBINA anunciam uma parceria com vista a reaproveitar o anti-histamínico azelastina para combater a COVID-19
- URSAPHARM Arzneimittel et CEBINA annoncent un partenariat pour reconvertir l'antihistaminique azélastine afin de lutter contre la COVID-19
- URSAPHARM Arzneimittel y CEBINA anuncian una colaboración para readaptar el antihistamínico azelastine para combatir la COVID-19
- URSAPHARM Arzneimittel and CEBINA announce partnership to repurpose the antihistamine azelastine to combat COVID-19
- ANIL UZUN Will Launch Bass Guitar Lessons Series on Youtube
- Henrik Stampe Appointed CEO for Mono Solutions
- Anna Mossberg leder Nordens största privata AI-lab i Sverige: "Utan AI riskerar svenska företag att förlora sin konkurrensfördel."
- What COVID-19 has taught us about manufacturing & the importance of a digital online marketplace
- Digi Communications N.V. announces: the Supreme Court of Hungary dismissed the Company’s appeal related to the 5G Tender procedure
- Customer Data Platform Industry to Reach $1.5 Billion in 2021: CDP Institute Report
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GreenMantra Technologies Announces Exclusive Distribution Relationship with HARKE GROUP